منابع مشابه
Thymus-marrow Immunocompetence
Corticosteroids suppress the humoral antibody response of mice to sheep erythrocytes. This response depends on interactions between thymus-derived helper cells and bone marrow-derived antibody-forming cell precursors (AFC precursors). Previous experiments had shown that spleen cells (a mixture of thymus-derived and marrow-derived cells) were sensitive to corticosteroids while AFC precursors in ...
متن کاملOn Discovering Thymus–Marrow Synergism
In the 1960s, the thymus was an organ of mystery. Although it was full of lymphocytes, they made no antibodies. Furthermore, thymectomy (in mature animals) failed to produce immunological inadequacy. This situation changed when J.F.A.P. Miller did neonatal thymectomy, which was indeed followed by a syndrome including crippling of the immune response (1–3). The possible role of the thymus was th...
متن کاملThymus-dependent lymphocytes in human bone marrow.
Human bone marrow is known to contain significant numbers of bursa-dependent lymphocytes. The presence of thymus-dependent (T) cells is controversial. Bone marrow cells obtained from healthy volunteers was fractionated by density centrifugation. A lymphocte-enriched subpopulation was shown to be reactive to alloantigens in mixed lymphocyte culture and to contain substantial numbers of T lymphoc...
متن کاملImmunocompetence of Spleen Cells from Neonatally Thymectomized Mice Conferred in Vitro by a Syngeneic Thymus Extract
Impaired immunological competence of spleen cells from neonatally thymectomized C57B1/6 young adult mice was apparent when these cells were tested in an in vitro graft-versus-host assay. Spleen cell inocula prepared from thymectomized mice did not induce enlargement of (C3H/eb x C57BI/6)F(1) newborn spleen explants, whereas the same number of cells from intact donors consistently initiated sple...
متن کاملStudies on Some Physicochemical Properties of a Thymus Humoral Factor Conferring Immunocompetence on Lymphoid Cells
By means of an assay of graft-versus-host activity some properties of the thymic humoral factor which confers immunocompetence upon lymphoid cells in vitro have been studied. Allogeneic and xenogeneic thymic preparations were found to activate lymphoid cells from neonatally thymectomized mice, enabling initiation of a graft-versus-host response. Thus, this thymus factor is apparently neither st...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1971
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.133.5.1026